Please use this identifier to cite or link to this item: http://monografias.ufrn.br/handle/123456789/9531
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dc.contributor.advisorSilbiger, Vivian Nogueira-
dc.contributor.authorViana, Thamila Arianny Carlos-
dc.date.accessioned2019-11-22T18:02:36Z-
dc.date.available2019-11-22T18:02:36Z-
dc.date.issued2019-11-06-
dc.identifier2014094826pt_BR
dc.identifier.citationVIANA, Thamila Arianny Carlos. LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology. 2019. 29f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.pt_BR
dc.identifier.urihttp://monografias.ufrn.br/handle/123456789/9531-
dc.languageenpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.subjectAtrial fibrilationpt_BR
dc.subjectlncRNApt_BR
dc.subjectbiomarkerspt_BR
dc.subjectregulatory mechanismspt_BR
dc.titleLncRNA and atrial fibrillation: new perspectives for molecular pathophysiologypt_BR
dc.typebachelorThesispt_BR
dc.contributor.advisor-co1Ananília Medeiros Gomes da Silvapt_BR
dc.contributor.referees1Luchessi, André Ducati-
dc.contributor.referees2Sousa, Júlio César Vieira de-
dc.description.resumoBackground: Many studies have demonstrated the association of atrial fibrillation (AF) with endogenous genetic regulatory mechanisms, as non-coding RNAs that could explain how the pathophysiological process occurs and suggest a possible early detection for some diseases, contributed also to the control of progression, among which are long non-coding RNAs (lncRNA). The objective of this review is to report the studies that analyzed the expression of lncRNAs in AF and the main experimental results reported and discuss the importance of these findings. Methods and results: For the selection of studies, a search was conducted on the PubMed public database (www.ncbi.nlm.nih.gov/pubmed) using the terms “lncRNA and atrial fibrillation” or “long ncRNA and atrial fibrillation” or “non-coding long RNA and atrial fibrillation”. Twenty studies were identified in this research. Of these, one is a review article, four articles in which lncRNAs were not related and fifteen represent original research. Of the 15 studies that continued in our review 10 were in tissue samples, 3 were in blood samples and 2 in vitro cell samples. No lncRNA was repeated, we attributed these variations to the sample type, method, species, and patient classification approached in the studies. Conclusion: The role of lncRNAs and the pathophysiology of atrial fibrillation is not yet well understood, so there is a need to encourage studies to elucidate this role.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFarmáciapt_BR
dc.publisher.initialsUFRNpt_BR
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