Please use this identifier to cite or link to this item: http://monografias.ufrn.br/handle/123456789/11778
Title: Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
Authors: Macedo, Pollyana Cristina de Oliveira
Keywords: Euterpe oleracea;Inclusion complexes;Antioxidant;Anti-inflammatory
Issue Date: 8-Apr-2021
Publisher: Universidade Federal do Rio Grande do Norte
Citation: MACEDO, Pollyana Cristina de Oliveira. Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin. 2021. 26f. Trabalho de conclusão de curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2021.
Portuguese Abstract: Reactive oxygen species (ROS) are aerobic products generated during cellular respiration, but in case of oxidative stress, they become key factors in the development of inflammatory processes and chronic diseases, such as diabetes and rheumatoid arthritis. In this work, Euterpe oleracea oil (EOO), as well as the complexes produced by slurry and kneading, were analyzed for antioxidant capacity in vitro, meanwhile the EOO-β-CD (M) complex was selected for anti-inflammatory assays in vivo. In the scavenging activity of OH., EOO-HP-β-CD (M) exhibited an activity 437% better than pure oil. In the paw edema assay, EOO-β-CD (M) reduced edema by 200% and myeloperoxidase (MPO) activity by 112%. In an air pouch model, this treatment showed a reduction in leukocyte, MPO and Interleukin-1β (IL-1β) levels, meanwhile glutathione and IL-10 were increased, demonstrating to potentiate the anti-inflammatory effect of EOO.
URI: http://monografias.ufrn.br/handle/123456789/11778
Other Identifiers: 20150118774
Appears in Collections:Farmácia

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