Please use this identifier to cite or link to this item: http://monografias.ufrn.br/handle/123456789/10672
Title: 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
Other Titles: 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
Authors: Farias, Pablo Felipe Ferreira
Keywords: 12-HSA;curcumin;self-assembly;12-Hydroxystearic acid
Issue Date: 10-Jul-2020
Publisher: Universidade Federal do Rio Grande do Norte
Citation: FARIAS, Pablo Felipe Ferreira. 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach. 2020. 32 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020.
Portuguese Abstract: 12-Hydroxystearic acid (12-HSA)-based organogels are self-assembled systems that allow trapping organic solvents, such as natural oils. Therefore, they are excellent choice in the pharmaceutical field to load lipophilic molecules. Based on this, the aim of this study was to obtain 12-HSA-based organogels loading curcumin at different concentrations of the organogelator (2, 5 and 10 % w / w) in Miglyol ® 812 N, a medium chain triglyceride widely used in the pharmaceutical field. The physicochemical, thermal and mechanical properties of the produced organogels were elucidated by techniques, such as FTIR, XRD, visual sol-gel temperature transition and texture analysis. The characterization assays revealed that the organogels have an amorphous due to the oil composition. It also demonstrated that the model molecule, curcumin, was solubilized in the oil, which was entrapped by the crystalline matrix. Additionally, the thermal profile of the systems at different 12-HSA concentrations demonstrated the thermoreversible property of the gels and the addition of curcumin did not interfere in this property, which in general it may suggest a thermal stability profile that allows its storage at high temperatures. The mechanical profile results pointed out the possibility of use in several administration routes depending on the gelling agent concentration. Thereafter, it was possible to verify that the addition of the drug did not change the physicochemical and mechanical properties of the 12-HSA organogels, suggesting that this system is able to trap other drug other drug candidates. In view of these results, it is noteworthy the versatility of such organogels based on their amorphous nature and variable hardness, which could preclude their use in different field applications. The system could also become a viable delivery system to a wide range of drugs once they do not interfere on their characteristics. Therefore, for its future use, additional release, safety and biological activity studies need to be carried out.
URI: http://monografias.ufrn.br/handle/123456789/10672
Other Identifiers: 20160127641
Appears in Collections:Farmácia

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